The enigma of primary Raynaud's disease.

@article{Coffman1989TheEO,
  title={The enigma of primary Raynaud's disease.},
  author={Jay D. Coffman},
  journal={Circulation},
  year={1989},
  volume={80 4},
  pages={1089-90}
}
D espite many years of investigation, the pathophysiology of vasospastic attacks in primary (idiopathic) Raynaud's disease is unknown. In secondary Raynaud's phenomenon, it is understandable that digital arteries may close during normal sympathetic stimuli or external pressure on the fingers due to low blood pressure distal to stenoses or obstructions or thickened vessel walls or to decreased blood flow caused by increased blood viscosity or persistent vasoconstriction. Digital arterial disease… CONTINUE READING