The enigma of neuromelanin in Parkinson's disease substantia nigra.

@article{Youdim1994TheEO,
  title={The enigma of neuromelanin in Parkinson's disease substantia nigra.},
  author={Moussa B. H. Youdim and Dorit Ben-Shachar and Peter Franz Riederer},
  journal={Journal of neural transmission. Supplementum},
  year={1994},
  volume={43},
  pages={113-22}
}
The function of neuromelanin accumulation in the nigrostriatal dopamine neurons remains uncertain. Nevertheless, it is recognized that neuromelanin disappearance parallels the loss of dopamine neurons in Parkinson's disease, suggesting its participation in nigral cell death. It has been well known for some years that in systemic tissues melanin is a double-edged sword. On the one hand it can act as an antioxidant, but in the presence of transitional metals (primarily, iron) and drugs it… CONTINUE READING