The enhancing effects of peptidase inhibitors on the antinociceptive action of [Met5]enkephalin-Arg6-Phe7 in rats.

@article{Takahashi2007TheEE,
  title={The enhancing effects of peptidase inhibitors on the antinociceptive action of [Met5]enkephalin-Arg6-Phe7 in rats.},
  author={Shigeru Takahashi and Xing Lu Jin and Kenya Kosaka and Masanobu Yoshikawa and Hiroyuki Kobayashi and Tetsuo Oka},
  journal={Journal of pharmacological sciences},
  year={2007},
  volume={105 1},
  pages={117-21}
}
Previous in vitro studies have shown that the degradation of [Met(5)]enkephalin-Arg(6)-Phe(7) during incubation with cerebral membrane preparations is largely prevented by a mixture of three peptidase inhibitors: amastatin, captopril, and phosphoramidon. The present in vivo study shows that the inhibitory effect of [Met(5)]enkephalin-Arg(6)-Phe(7… CONTINUE READING