The enhancing effects of peptidase inhibitors on the antinociceptive action of [Met5]enkephalin-Arg6-Phe7 in rats.

@article{Takahashi2007TheEE,
  title={The enhancing effects of peptidase inhibitors on the antinociceptive action of [Met5]enkephalin-Arg6-Phe7 in rats.},
  author={Shigeru Takahashi and X. Jin and K. Kosaka and M. Yoshikawa and Hiroyuki Kobayashi and T. Oka},
  journal={Journal of pharmacological sciences},
  year={2007},
  volume={105 1},
  pages={
          117-21
        }
}
Previous in vitro studies have shown that the degradation of [Met(5)]enkephalin-Arg(6)-Phe(7) during incubation with cerebral membrane preparations is largely prevented by a mixture of three peptidase inhibitors: amastatin, captopril, and phosphoramidon. The present in vivo study shows that the inhibitory effect of [Met(5)]enkephalin-Arg(6)-Phe(7) administered intra-third-ventricularly on the tail-flick response was increased more than 1000-fold by the intra-third-ventricular pretreatment with… Expand
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