The enhancing effect of anionic alpha-helical peptide on cationic peptide-mediating transfection systems.

@article{Ohmori1997TheEE,
  title={The enhancing effect of anionic alpha-helical peptide on cationic peptide-mediating transfection systems.},
  author={N. Ohmori and T. Niidome and A. Wada and T. Hirayama and T. Hatakeyama and H. Aoyagi},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={235 3},
  pages={
          726-9
        }
}
A peptide consisting of 12 amino acids including 3 glutamic acids (LAEL-LAEL-LAEL; 4(3)E) underwent pH-dependent conformational change from random coil to alpha-helix when the pH was decreased from 7.4 to 5.0 in the presence of egg PC. This alpha-helical 4(3)E had higher membrane-perturbation activity at acidic conditions compared with neutral conditions. When 4(3)E was incorporated with plasmid DNA-cationic peptide complex that utilizes an endocytosis pathway for uptake into cultured cells… Expand
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