The enhancement of specific antibody production rate in glucose- and glutamine-controlled fed-batch culture

@article{Omasa1992TheEO,
  title={The enhancement of specific antibody production rate in glucose- and glutamine-controlled fed-batch culture},
  author={Takeshi Omasa and Masaru Ishimoto and Ken-ichi Higashiyama and Suteaki Shioya and Ken-ichi Suga},
  journal={Cytotechnology},
  year={1992},
  volume={8},
  pages={75-84}
}
The concentration effects of certain amino acids (Asp, Ile, Leu, Lys, Met, Val, Phe and Gln which were highly consumed during cultivation), and glucose on cell growth and antibody productivity were investigated using dish culture. From these experiments, it was found that only glutamine enrichment enhanced the specific antibody production rate. The other amino acids described above did not affect either the specific growth rate or specific antibody production rate. Thus we investigated the… CONTINUE READING