The enhancement of neutron irradiation of HeLa-S cervix carcinoma cells by cell-nucleus-addressed deca-p-boronophenylalanine.

@article{Braun2003TheEO,
  title={The enhancement of neutron irradiation of HeLa-S cervix carcinoma cells by cell-nucleus-addressed deca-p-boronophenylalanine.},
  author={Klaus Braun and Gerd Wolber and Waldemar Waldeck and Ruediger Pipkorn and J{\"u}rgen W. Jenne and Ralf Rastert and Volker Ehemann and Andreas Eisenmenger and Heike Corban-Wilhelm and Isabell Braun and Steffen M. Heckl and Juergen Debus},
  journal={European journal of medicinal chemistry},
  year={2003},
  volume={38 6},
  pages={
          587-95
        }
}
Boron neutron capture therapy (BNCT) is an experimental treatment modality which depends on a sufficient cellular uptake of Boron ((10)B) followed by an exposure to a thermal neutron beam from a nuclear reactor. High energetic particles (4He and 7Li) are created during the neutron capture reaction and produce DNA damages, which lead to cell killing. Regarding BNCT, the short radiation range of He- and Li-particles is decisive for the distribution of (10)B. Until now, BNCT has been lacking for… CONTINUE READING