The enhanced sensitivity of mammalian cells to killing by X rays after prolonged exposure to several nitroimidazoles.

@article{Hall1982TheES,
  title={The enhanced sensitivity of mammalian cells to killing by X rays after prolonged exposure to several nitroimidazoles.},
  author={Eric Joseph Hall and Michael Astor and John E. Biaglow and J. C. Parham},
  journal={International journal of radiation oncology, biology, physics},
  year={1982},
  volume={8 3-4},
  pages={447-51}
}
Electron affinic compounds, such as misonidazole, preferentially sensitize hypoxic cells to killing by X rays, and are also preferentially cytotoxic to cells deficient in oxygen. Prolonged exposure of cells to misonidazole prior to irradiation results in an increased radiosensitization. This is expressed as the Extra Enhancement Ratio (EER), defined as the ratio of the doses delivered immediately after the addition of the sensitizer or after prolonged incubation, that produce a given biological… CONTINUE READING