The enhanced performance of bone allografts using osteogenic-differentiated adipose-derived mesenchymal stem cells.

@article{Schubert2011TheEP,
  title={The enhanced performance of bone allografts using osteogenic-differentiated adipose-derived mesenchymal stem cells.},
  author={Thomas Schubert and Daela Xhema and Sophie V{\'e}riter and Micha{\"e}l Schubert and Catherine Nyssen Behets and C. Delloye and Pierre Rene Gianello and Denis Dufrane},
  journal={Biomaterials},
  year={2011},
  volume={32 34},
  pages={8880-91}
}
Adipose tissue was only recently considered as a potential source of mesenchymal stem cells (MSCs) for bone tissue engineering. To improve the osteogenicity of acellular bone allografts, adipose MSCs (AMSCs) and bone marrow MSCs (BM-MSCs) at nondifferentiated and osteogenic-differentiated stages were investigated in vitro and in vivo. In vitro experiments demonstrated a superiority of AMSCs for proliferation (6.1±2.3 days vs. 9.0±1.9 days between each passage for BM-MSCs, respectively, P<0.001… CONTINUE READING
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