The enhanced immune response of hepatitis B virus DNA vaccine using SiO2@LDH nanoparticles as an adjuvant.

@article{Wang2014TheEI,
  title={The enhanced immune response of hepatitis B virus DNA vaccine using SiO2@LDH nanoparticles as an adjuvant.},
  author={Jin Wang and Rongrong Zhu and Bo Gao and Bin Wu and Yubin Li and Xiaoyu Sun and Hui Liu and Shilong Wang},
  journal={Biomaterials},
  year={2014},
  volume={35 1},
  pages={466-78}
}
Various approaches have been used to improve systemic immune response to infectious disease or virus, and DNA vaccination has been demonstrated to be one of these effective ways to elicit protective immunity against pathogens. Our previous studies showed that layered double hydroxides (LDH) nanoparticles could be efficiently taken up by the MDDCs and had an adjuvant activity for DC maturation. To further enhance the immune adjuvant activity of LDH, core-shell structure SiO2@LDH nanoparticles… CONTINUE READING

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