The enhanced anti-angiogenic and antitumor effects of combining flk1-based DNA vaccine and IP-10.

@article{Lu2008TheEA,
  title={The enhanced anti-angiogenic and antitumor effects of combining flk1-based DNA vaccine and IP-10.},
  author={Xiao-ling Lu and Xiaobing Jiang and Ru-en Liu and Sheng-min Zhang},
  journal={Vaccine},
  year={2008},
  volume={26 42},
  pages={5352-7}
}
The purpose of the present study was to evaluate the anti-vasculature effects and the anti-tumor effects of attenuated Salmonella typhimurium vaccine strain encoding murine vascular endothelial growth factor (VEGF) receptor-2 (flk1) in combination with plasmid DNA vector encoding the murine interferon-induced protein of 10kDa (IP-10 or CXCL10) gene. Mouse models of malignant melanoma (B16-F10) were treated with combining orally given attenuated S. typhimurium vaccine strain encoding flk1 with… CONTINUE READING
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