The engine driving the ship: metabolic steering of cell proliferation and death

  title={The engine driving the ship: metabolic steering of cell proliferation and death},
  author={Marisa R Buchakjian and Sally Kornbluth},
  journal={Nature Reviews Molecular Cell Biology},
Metabolic activity is a crucial determinant of a cell's decision to proliferate or die. Although it is not fully understood how metabolic pathways such as glycolysis and the pentose phosphate pathway communicate to cell cycle and apoptotic effectors, it is clear that a complex network of signalling molecules is required to integrate metabolic inputs. D-type cyclins, cyclin-dependent kinases, the anaphase-promoting complex, p53, caspase 2 and B cell lymphoma 2 proteins, among others, have been… CONTINUE READING


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