The energetic network of hotspot residues between Cdc25B phosphatase and its protein substrate.

Abstract

We have investigated the functional network of hotspot residues at the remote docking site of two cell cycle regulators, namely Cdc25B phosphatase and its native protein substrate Cdk2-pTpY/CycA. Specifically, we have studied the roles of energetically important residues (Arg488, Arg492, Tyr497 on Cdc25B and Asp206 and Asp210 on Cdk2-pTpY/CycA) by… (More)

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@article{Sohn2006TheEN, title={The energetic network of hotspot residues between Cdc25B phosphatase and its protein substrate.}, author={Jungsan Sohn and Johannes Rudolph}, journal={Journal of molecular biology}, year={2006}, volume={362 5}, pages={1060-71} }