The enduring effects of abuse and related adverse experiences in childhood

@article{Anda2005TheEE,
  title={The enduring effects of abuse and related adverse experiences in childhood},
  author={Robert F. Anda and Vincent J. Felitti and James Douglas Bremner and John D. Walker and Charles L. Whitfield and Bruce D. Perry and Shanta R. Dube and Wayne H. Giles},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={2005},
  volume={256},
  pages={174-186}
}
  • R. Anda, V. Felitti, +5 authors W. Giles
  • Published 1 April 2006
  • Medicine
  • European Archives of Psychiatry and Clinical Neuroscience
BackgroundChildhood maltreatment has been linked to a variety of changes in brain structure and function and stress–responsive neurobiological systems. Epidemiological studies have documented the impact of childhood maltreatment on health and emotional well–being.MethodsAfter a brief review of the neurobiology of childhood trauma, we use the Adverse Childhood Experiences (ACE) Study as an epidemiological “case example” of the convergence between epidemiologic and neurobiological evidence of the… 
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TLDR
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The study highlights the profound consequence of child abuse/neglect and identifies self-esteem as a plausible mediating mechanism and researchers and practitioners should increase collaboration efforts to prevent early adversity exposures and detrimental effects on mental health.
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