The endotoxemia cardiac dysfunction is attenuated by AMPK/mTOR signaling pathway regulating autophagy.

@article{Zhang2017TheEC,
  title={The endotoxemia cardiac dysfunction is attenuated by AMPK/mTOR signaling pathway regulating autophagy.},
  author={Jie Zhang and Peng Zhao and Nanhu Quan and Lin Wang and Xu Chen and Courtney A Cates and Thomas Rousselle and Ji Li},
  journal={Biochemical and biophysical research communications},
  year={2017},
  volume={492 3},
  pages={520-527}
}
AMP-activated protein kinase (AMPK), an enzyme that plays a role in cellular energy homeostasis, modulates myocardial signaling in the heart. Myocardial dysfunction is a common complication of sepsis. Autophagy is involved in the aging related cardiac dysfunction. However, the role of AMPK in sepsis-induced cardiotoxicity has yet to be clarified, especially in aging. In this study, we explored the role of AMPK in lipopolysaccharide (LPS)-induced myocardial dysfunction and elucidated the… CONTINUE READING