The endothelin system in human saphenous vein graft disease.

  title={The endothelin system in human saphenous vein graft disease.},
  author={Anthony P. Davenport and Janet J. Maguire},
  journal={Current opinion in pharmacology},
  volume={1 2},
Saphenous vein graft stenosis is a significant clinical complication for coronary artery bypass patients. Endothelin-1, a peptide synthesised by vascular endothelial cells, is the most potent known vasoconstrictor and has mitogenic properties. Recent advances in our knowledge of endothelin-1 synthesis and endothelin receptor expression and function in normal and atherosclerotic human saphenous vein imply a role for the peptide in the progression of vein graft failure. Manipulation of the… CONTINUE READING
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