The endothelin system and its potential as a therapeutic target in cardiovascular disease.

@article{Gray1996TheES,
  title={The endothelin system and its potential as a therapeutic target in cardiovascular disease.},
  author={Gillian A Gray and David J. Webb},
  journal={Pharmacology & therapeutics},
  year={1996},
  volume={72 2},
  pages={109-48}
}
Endothelin (ET)-1, an endothelium-derived peptide, is the most potent vasoconstrictor agent described to date. ET-1 also has positive inotropic and chronotropic effects in the heart and is a co-mitogen in both cardiac and vascular myocytes. The major elements of the system involved in formation of ET-1 and its isopeptides, as well as the receptors mediating their effects, have been cloned and characterised. Antagonists of the ET receptors are now available, and selective inhibitors of the ET… CONTINUE READING

From This Paper

Topics from this paper.
44 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

Similar Papers

Loading similar papers…