The endothelin receptor-B is required for the migration of neural crest-derived melanocyte and enteric neuron precursors.

@article{Lee2003TheER,
  title={The endothelin receptor-B is required for the migration of neural crest-derived melanocyte and enteric neuron precursors.},
  author={Hyung-Ok Lee and John M. Levorse and Myung Kyun Shin},
  journal={Developmental biology},
  year={2003},
  volume={259 1},
  pages={162-75}
}
Mutations in the genes encoding endothelin receptor-B (Ednrb) and its ligand endothelin-3 (Edn3) affect the development of two neural crest-derived cell types, melanocytes and enteric neurons. EDNRB signaling is exclusively required between E10.5 and E12.5 during the migratory phase of melanoblast and enteric neuroblast development. To determine the fate of Ednrb-expressing cells during this critical period, we generated a strain of mice with the bacterial beta-galactosidase (lacZ) gene… CONTINUE READING
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