The endothelin-integrin axis is involved in macrophage-induced breast cancer cell chemotactic interactions with endothelial cells.

@article{Chen2014TheEA,
  title={The endothelin-integrin axis is involved in macrophage-induced breast cancer cell chemotactic interactions with endothelial cells.},
  author={Chia-Chi V Chen and Li-Li Chen and Yu-Ting Hsu and Ko-Jiunn Liu and Chi-Shuan Fan and Tze-Sing Huang},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 14},
  pages={10029-44}
}
Elevated macrophage infiltration in tumor tissues is associated with breast cancer metastasis. Cancer cell migration/invasion toward angiogenic microvasculature is a key step in metastatic spread. We therefore studied how macrophages stimulated breast cancer cell interactions with endothelial cells. Macrophages produced cytokines, such as interleukin-8 and… CONTINUE READING