The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.

@article{Disse2011TheEP,
  title={The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.},
  author={Jennifer Disse and Helle Heibroch Petersen and Katrine Strandberg Larsen and Egon Persson and Naomi L. Esmon and Charles T. Esmon and Luc Teyton and Lars Christian Petersen and Wolfram Ruf},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 7},
  pages={5756-67}
}
Protease-activated receptor (PAR) signaling is closely linked to the cellular activation of the pro- and anticoagulant pathways. The endothelial protein C receptor (EPCR) is crucial for signaling by activated protein C through PAR1, but EPCR may have additional roles by interacting with the 4-carboxyglutamic acid domains of procoagulant coagulation factors… CONTINUE READING