The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure.

@article{Cat2010TheEM,
  title={The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure.},
  author={Aur{\'e}lie Nguyen Dinh Cat and Violaine Griol-Charhbili and Laurent Loufrani and Carlos Labat and Laura E. Benjamin and Nicolette Farman and Patrick Lacolley and Daniel Henrion and Fr{\'e}d{\'e}ric Jaisser},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2010},
  volume={24 7},
  pages={2454-63}
}
Pathophysiological aldosterone (aldo)/mineralocorticoid receptor (MR) signaling has significant effects on the cardiovascular system, resulting in hypertension and cardiovascular remodeling; however, the specific contribution of the vascular MR to blood pressure regulation remains to be established. To address this question, we generated a mouse model with conditional overexpression of the MR in endothelial cells (MR-EC). In basal conditions, MR-EC mice developed moderate hypertension that… CONTINUE READING

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