The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling

@article{Gleeson2011TheEC,
  title={The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling},
  author={Eimear M. Gleeson and James S. O’Donnell and Roger J S Preston},
  journal={Cellular and Molecular Life Sciences},
  year={2011},
  volume={69},
  pages={717-726}
}
Increasing evidence links blood coagulation proteins with the regulation of acute and chronic inflammatory disease. Of particular interest are vitamin K-dependent proteases, which are generated as a hemostatic response to vascular injury, but can also initiate signal transduction via interactions with vascular receptors. The endothelial cell protein C receptor (EPCR) is a multi-ligand vitamin K-dependent protein receptor for zymogen and activated forms of plasma protein C and factor VII… CONTINUE READING
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The crystal structure of the endothelial protein C receptor and a bound phospholipid

  • V Oganesyan
  • J Biol Chem
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