The endothelial and non-endothelial mechanism responsible for attenuated vasoconstriction in cirrhotic rats.

@article{Obbergh1995TheEA,
  title={The endothelial and non-endothelial mechanism responsible for attenuated vasoconstriction in cirrhotic rats.},
  author={Luc J Van Obbergh and Victoria Wynn Leonard and Haiping Chen and Dazhong Xu and Gilbert Blaise},
  journal={Experimental physiology},
  year={1995},
  volume={80 4},
  pages={609-17}
}
The pathogenesis of the vasodilatation associated with liver cirrhosis is not fully understood, but it has recently been postulated that it may be related to an increase in nitric oxide production. The aim of this study was to compare the response of isolated aortic rings from normal and cirrhotic rats to two vasoconstrictors, phenylephrine and U46619, a thromboxane analogue. Biliary cirrhosis was induced by ligation of the common bile duct; a sham operation was performed in control animals… CONTINUE READING