The endoplasmic reticulum stress response in the pancreatic β-cell.

@article{Volchuk2010TheER,
  title={The endoplasmic reticulum stress response in the pancreatic β-cell.},
  author={Allen Volchuk and David Ron},
  journal={Diabetes, obesity & metabolism},
  year={2010},
  volume={12 Suppl 2},
  pages={48-57}
}
Eukaryotic cells respond to stress in the endoplasmic reticulum (ER) resulting from insufficient protein folding capacity or altered ER homeostasis by activating the unfolded protein response (UPR). In mammalian cells the UPR is mediated by at least three ER-localized sensors/transducers, and the cellular response and susceptibility to ER stress is likely to be cell-type specific to some degree. Here, we review the response of pancreatic β-cells or islets to ER stress induced by pharmacological… CONTINUE READING