The endoplasmic reticulum stress response in aging and age-related diseases

@article{Brown2012TheER,
  title={The endoplasmic reticulum stress response in aging and age-related diseases},
  author={Marishka Brown and Nirinjini Naidoo},
  journal={Frontiers in Physiology},
  year={2012},
  volume={3}
}
The endoplasmic reticulum(ER) is a multifunctional organelle within which protein folding, lipid biosynthesis, and calcium storage occurs. Perturbations such as energy or nutrient depletion, disturbances in calcium or redox status that disrupt ER homeostasis lead to the misfolding of proteins, ER stress and up-regulation of several signaling pathways coordinately called the unfolded protein response (UPR). The UPR is characterized by the induction of chaperones, degradation of misfolded… 

Figures from this paper

The unfolded protein response and cellular senescence. A review in the theme: cellular mechanisms of endoplasmic reticulum stress signaling in health and disease.

The interconnections between the UPR signaling and the different aspects of the cellular senescence programs are described and the implication of UPR modulations in this context is discussed.

Endoplasmic Reticulum Stress Coping Mechanisms and Lifespan Regulation in Health and Diseases

The role of ER stress response pathways in age-dependent neurodegeneration is reviewed to give a brief overview of the role they play in lifespan regulation under both normal and disease states.

The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling

The endoplasmic reticulum is discussed, cellular fate during ER stress, cross talk between the ER and mitochondria and its significance, and conditions that can trigger ER stress response failure.

Crosstalk between Endoplasmic Reticulum Stress and Protein Misfolding in Neurodegenerative Diseases

Increasing understanding about the deadly crosstalk between ER dysfunction and protein misfolding in these neurodegenerative diseases may stimulate the development of novel therapeutic strategies able to support neuronal survival and ameliorate disease progression.

Endoplasmic Reticulum Unfolded Protein Response and Aging: Causality, Mechanism, and Interplay

  • Chang-Chun Li
  • Biology
    2022 6th International Conference on Biomedical Engineering and Applications (ICBEA)
  • 2022
Recent advances in determining UPRER's role in aging were discussed and its interconnection with other stress response pathways, aging hallmarks, and phenotypical markers of aging are discussed to provide a more holistic view of aging.

The Role of Endoplasmic Reticulum Protein Quality Control in Longevity

Novel therapeutic approaches to promote health and extend lifespan through endogenous molecule modulation of protein quality control, and hence, might be important for future studies of neurodegenerative disorders.

Interrelation Between Protein Synthesis, Proteostasis and Life Span

This review will summarize cellular strategies to regulate mRNA translation upon stress and its impact on longevity.

Alzheimer’s disease pathology and the unfolded protein response: prospective pathways and therapeutic targets

The functions of the ER and UPR are summarized, evidence for its potential role in the pathogenesis of Alzheimer’s disease is highlighted, and several key targets with therapeutic potential are discussed.

Evolution of the unfolded protein response.

  • J. Hollien
  • Biology
    Biochimica et biophysica acta
  • 2013

X‐box binding protein 1 (XBP1) function in diseases

The latest research progress of IRE1‐XBP1 pathway in cancer, metabolic diseases, and other diseases was briefly introduced, and the relationship between several diseases and this pathway was analyzed.
...

References

SHOWING 1-10 OF 171 REFERENCES

Endoplasmic Reticulum Stress and Atherosclerosis

This review summarizes the recent understanding of ER stress signaling in the pathogenesis of atherosclerosis.

Translational control in the endoplasmic reticulum stress response.

  • D. Ron
  • Biology
    The Journal of clinical investigation
  • 2002
The phenotypes of mutations affecting components of the ER stress-response machinery reveal that ER stress is also a normal physiological phenomenon.

ER stress and the unfolded protein response.

The mammalian unfolded protein response.

In the endoplasmic reticulum (ER), secretory and transmembrane proteins fold into their native conformation and undergo posttranslational modifications important for their activity and structure.

From acute ER stress to physiological roles of the Unfolded Protein Response

There is a growing body of data that suggest that different subpathways of the UPR are required throughout the entire life of eucaryotic organisms, from regulation of differentiation to induction of apoptosis.

Endoplasmic Reticulum Stress and Lipid Metabolism: Mechanisms and Therapeutic Potential

Recent findings illustrating the important role ER stress/UPR signalling pathways play in regulation of lipid metabolism, and how they may lead to dysregulation of lipid homeostasis are examined.

ER stress and the unfolded protein response in intestinal inflammation.

Evidence is reviewed from mouse models and human inflammatory bowel diseases that ties ER stress and activation of the UPR with intestinal inflammation, and possible therapeutic approaches to ameliorate ER stress are discussed.

Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling

It is demonstrated here that aging impairs this adaptive response to sleep deprivation, which is associated with higher levels of GADD34 and proapoptotic proteins such as CCAAT/enhancer-binding protein-homologous protein and activated caspase-12, suggesting that young animals possess an efficient ER adaptive response that declines with aging.

The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration.

The most recent evidence addressing the role of the UPR and ER stress in neurodegenerative disorders is reviewed here, along with therapeutic strategies to alleviateER stress in a disease context.
...