The endoplasmic reticulum stress response in aging and age-related diseases

  title={The endoplasmic reticulum stress response in aging and age-related diseases},
  author={Marishka Brown and Nirinjini Naidoo},
  journal={Frontiers in Physiology},
The endoplasmic reticulum(ER) is a multifunctional organelle within which protein folding, lipid biosynthesis, and calcium storage occurs. Perturbations such as energy or nutrient depletion, disturbances in calcium or redox status that disrupt ER homeostasis lead to the misfolding of proteins, ER stress and up-regulation of several signaling pathways coordinately called the unfolded protein response (UPR). The UPR is characterized by the induction of chaperones, degradation of misfolded… 

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