The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

  title={The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages},
  author={Bo Feng and Pin Mei Yao and Yankun Li and Cecilia M. Devlin and Dajun Zhang and Heather P Harding and Michele A Sweeney and James Xiaojun Rong and George Kuriakose and Edward A Fisher and Andrew Robert Marks and David Ron and Ira Tabas},
  journal={Nature Cell Biology},
Excess cellular cholesterol induces apoptosis in macrophages, an event likely to promote progression of atherosclerosis. The cellular mechanism of cholesterol-induced apoptosis is unknown but had previously been thought to involve the plasma membrane. Here we report that the unfolded protein response (UPR) in the endoplasmic reticulum is activated in cholesterol-loaded macrophages, resulting in expression of the cell death effector CHOP. Cholesterol loading depletes endoplasmic reticulum… CONTINUE READING
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