The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family

@article{HeathEngel2008TheER,
  title={The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family},
  author={Hannah M. Heath-Engel and Natasha C. Chang and Gordon C. Shore},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={6419-6433}
}
Apoptosis is essential for normal development and maintenance of homeostasis, and disruption of apoptotic pathways is associated with multiple disease states, including cancer. Although initially identified as central regulators of apoptosis at the level of mitochondria, an important role for BCL-2 proteins at the endoplasmic reticulum is now well… CONTINUE READING