The endonuclease domain of MutL interacts with the β sliding clamp.


Mismatch repair corrects errors that have escaped polymerase proofreading enhancing replication fidelity by at least two orders of magnitude. The β and PCNA sliding clamps increase the polymerase processivity during DNA replication and are important at several stages of mismatch repair. Both MutS and MutL, the two proteins that initiate the mismatch repair… (More)
DOI: 10.1016/j.dnarep.2010.10.003


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