The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.

@article{DuSell2010TheES,
  title={The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.},
  author={Carolyn D DuSell and Erik R Nelson and Xiaojuan Wang and Jennifer Abdo and Ulrike I L M{\"o}dder and Michihisa Umetani and Diane Gesty-Palmer and Norman B. Javitt and Sundeep Khosla and Donald P McDonnell},
  journal={Endocrinology},
  year={2010},
  volume={151 8},
  pages={3675-85}
}
Osteoporosis is an important clinical problem, affecting more than 50% of people over age 50 yr. Estrogen signaling is critical for maintaining proper bone density, and the identification of an endogenous selective estrogen receptor (ER) modulator, 27-hydroxycholesterol (27HC), suggests a mechanism by which nutritional/metabolic status can influence bone biology. With its levels directly correlated with cholesterol, a new possibility emerges wherein 27HC links estrogen and cholesterol signaling… CONTINUE READING

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