The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes.

@article{Tolosa2012TheER,
  title={The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes.},
  author={Jorge M. Tolosa and John E. Schjenken and Vicki L Clifton and Amandine Vargas and Benoit Barbeau and Peter M Lowry and Kaushik Maiti and Roger Smith},
  journal={Placenta},
  year={2012},
  volume={33 11},
  pages={933-41}
}
OBJECTIVES To examine whether syncytin-1 has immune regulatory functions and is carried by human placental exosomes. Further, to examine whether corticotropin-releasing hormone (CRH) can induce the production of syncytin-1. STUDY DESIGN Human placental exosomes were isolated from placental explant, primary trophoblast and BeWo cell cultures. The presence of exosomes was confirmed by transmission electron microscopy and western blotting. Exosomal protein was probed with 3 separate antibodies… CONTINUE READING