The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors
@article{Costa2008TheEF, title={The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPAR$\gamma$ receptors and neurotrophic factors}, author={Barbara Costa and Francesca Comelli and Isabella Bettoni and Mariapia Colleoni and Gabriella Giagnoni}, journal={PAIN}, year={2008}, volume={139}, pages={541-550} }
264 Citations
Fatty Acid Amide Hydrolase (FAAH) Inhibitors Exert Pharmacological Effects, but Lack Antinociceptive Efficacy in Rats with Neuropathic Spinal Cord Injury Pain
- Biology, MedicinePloS one
- 2014
Increasing CNS FAA levels alone does not lead to robust amelioration of below-level neuropathic SCI pain, and utilizing FAAH inhibition in conjunction with other analgesic mechanisms could be an effective analgesic therapy.
The role of transient receptor potential vanilloid receptor 1 and peroxisome proliferator-activated receptors-&agr; in mediating the antinociceptive effects of palmitoylethanolamine in rats
- BiologyNeuroreport
- 2019
Modulating transient receptor potential vanilloid receptor 1 activity could provide the mechanism that underlies PEA antinociceptive effects observed in vivo.
Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma
- Biology, MedicineJournal of Neuroinflammation
- 2012
It is indicated that PPAR-δ and PPar-γ can also contribute to the anti-inflammatory activity of PEA in SCI, as evaluated by the degree of spinal cord inflammation and tissue injury, neutrophil infiltration, proinflammmatory cytokine, inducible nitric oxide synthase expression and motor function.
N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism
- BiologyPain
- 2016
Data indicate that PEA in the ACC can reduce inflammatory pain-related behaviour, possibly via AEA-induced activation of CB1 receptors and associated modulation of neuronal activity in the basolateral amygdala.
Non-neuronal cell modulation relieves neuropathic pain: efficacy of the endogenous lipid palmitoylethanolamide.
- BiologyCNS & neurological disorders drug targets
- 2013
The data show that PEA delayed mast cell recruitment, protected mast cells against degranulation and abolished the nerve growth factor increase in sciatic nerve concomitantly preserving the nerve from degeneration, while reducing microglia activation in the spinal cord.
Efficacy of a Combination of N-Palmitoylethanolamide, Beta-Caryophyllene, Carnosic Acid, and Myrrh Extract on Chronic Neuropathic Pain: A Preclinical Study
- BiologyFront. Pharmacol.
- 2019
The rationale of using natural remedies in conjunction with classical pharmacological agents to treat chronic NP is supported, as Noxiall was efficacious also in reducing CCI-induced thermal hyperalgesia.
Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism
- BiologyPloS one
- 2013
It is suggested that intrathecally injected URB597 at full analgesic efficacy unmasks a secondary route of AEA metabolism via 15-LOX with possible formation of 15-hydroxy-AEA, which, together with OEA and PEA, may contribute at producing TRPV1-mediated analgesia in CCI rats.
The Interaction Between Intrathecal Administration of Low Doses of Palmitoylethanolamide and AM251 in Formalin-Induced Pain Related Behavior and Spinal Cord IL1-β Expression in Rats
- Biology, MedicineNeurochemical Research
- 2011
The findings suggest the possible involvement of receptors other than CB1 receptors in spinal pain pathways, such as GPR55, in pain modulating activity of cannabinoids.
Involvement of the L‐arginine/nitric oxide/cyclic guanosine monophosphate pathway in peripheral antinociception induced by N‐palmitoyl‐ethanolamine in rats
- BiologyJournal of neuroscience research
- 2012
Evidence is provided that PEA activates nNOS, thus initiating the NO/cGMP pathway and inducing peripheral antinociceptive effects, and that exogenous PEA is able to induce NO release.
The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain.
- BiologyPharmacological research
- 2016
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