The endogenous cannabinoid system controls extinction of aversive memories

@article{Marsicano2002TheEC,
  title={The endogenous cannabinoid system controls extinction of aversive memories},
  author={Giovanni Marsicano and Carsten T. Wotjak and Shahnaz Christina Azad and Tiziana Bisogno and Gerhard Rammes and Maria Grazia Cascio and Heike Hermann and Jianrong Tang and Clementine Hofmann and Walter Zieglg{\"a}nsberger and Vincenzo di Marzo and Beat Lutz},
  journal={Nature},
  year={2002},
  volume={418},
  pages={530-534}
}
Acquisition and storage of aversive memories is one of the basic principles of central nervous systems throughout the animal kingdom. In the absence of reinforcement, the resulting behavioural response will gradually diminish to be finally extinct. Despite the importance of extinction, its cellular mechanisms are largely unknown. The cannabinoid receptor 1 (CB1) and endocannabinoids are present in memory-related brain areas and modulate memory. Here we show that the endogenous cannabinoid… CONTINUE READING

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