The endogenous cannabinoid system and drug addiction: 20 years after the discovery of the CB1 receptor

  title={The endogenous cannabinoid system and drug addiction: 20 years after the discovery of the CB1 receptor},
  author={F. Rodr{\'i}guez de Fonseca and M. Schneider},
  journal={Addiction Biology},
  • F. Rodríguez de Fonseca, M. Schneider
  • Published 2008
  • Medicine, Psychology
  • Addiction Biology
  • Cannabis sativa preparations (hashish, marijuana) have been used by humans for the last 5000 years. But being one of the oldest recreational drugs with abuse potential, its neurobiological mechanisms remained obscure until the isolation and identification in 1964 of Dtetrahydrocannabinol (THC), its main psychoactive constituent, by the group of Ralph Mechoulam (Gaoni & Mechoulam 1964). THC was the first of a series of a new class of drugs termed cannabinoids, but despite this finding, the brain… CONTINUE READING
    15 Citations

    Topics from this paper

    Analysis of Synthetic Cannabinoids in Botanical Material: A Review of Analytical Methods and Findings.
    • 60
    • PDF
    Cannabinoids, interoception, and anxiety
    • 10
    Noradrenergic depletion causes sex specific alterations in the endocannabinoid system in the Murine prefrontal cortex
    A Novel Role of Cannabinoids in Synaptogenesis
    • PDF
    The brain endocannabinoid system in the regulation of energy balance.
    • 49
    EDITORIAL: Addiction Biology reaches new heights


    Molecular characterization of a peripheral receptor for cannabinoids
    • 4,243
    Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • 4,430
    Modulation of anxiety through blockade of anandamide hydrolysis
    • 841
    • PDF
    Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.
    • 2,496
    Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-Administration
    • 339
    • PDF
    A cannabinoid mechanism in relapse to cocaine seeking
    • 425
    • PDF
    Determination and characterization of a cannabinoid receptor in rat brain.
    • 2,090
    • Highly Influential
    • PDF
    Cannabinoid receptor localization in brain.
    • M. Herkenham, A. Lynn, +4 authors K. Rice
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1990
    • 1,978
    • Highly Influential
    Isolation and structure of a brain constituent that binds to the cannabinoid receptor.
    • 4,793
    • Highly Influential