The endogenous cannabinoid system and drug addiction: 20 years after the discovery of the CB1 receptor

  title={The endogenous cannabinoid system and drug addiction: 20 years after the discovery of the CB1 receptor},
  author={Fernando Rodr{\'i}guez de Fonseca and Miriam Schneider},
  journal={Addiction Biology},
Cannabis sativa preparations (hashish, marijuana) have been used by humans for the last 5000 years. But being one of the oldest recreational drugs with abuse potential, its neurobiological mechanisms remained obscure until the isolation and identification in 1964 of Dtetrahydrocannabinol (THC), its main psychoactive constituent, by the group of Ralph Mechoulam (Gaoni & Mechoulam 1964). THC was the first of a series of a new class of drugs termed cannabinoids, but despite this finding, the brain… 

Analysis of Synthetic Cannabinoids in Botanical Material: A Review of Analytical Methods and Findings.

The history of synthetic cannabinoids and how they have been detected in the illicit drug market is discussed and the analytical methods and techniques used by forensic scientists to analyze botanical products obtained via the Internet or from law enforcement investigations and arrests are discussed.

Cannabinoids, interoception, and anxiety

A Novel Role of Cannabinoids in Synaptogenesis

It is shown here that endogenous cannabinoids and their CHI receptors regulate the dendritic and axonal filopodia formation (synapse precursors) and synaptogenesis obtained from embryonic mice cortical cultures, confirming the previous observations showing that the activation of adenylate cyclase and P KA pathway produces a netrinl-DCC dependent increase insynaptogenesis.

The brain endocannabinoid system in the regulation of energy balance.

To Open Up New Vistas in Basic and Preclinical Addiction Research

This is a personal perspective on some of the major achievements in addiction research and an attempt to point out the most important future challenges in basic and preclinical research in this field.

EDITORIAL: Addiction Biology reaches new heights

In the past 5 years, there have been major changes in Addiction Biology. The complete Editorial Board has been exchanged and the focus of the journal is now based on basic and clinical neuroscience

Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors

  • T. Hayase
  • Psychology, Biology
    BMC Neuroscience
  • 2012
Although working memory impairment- and anxiety-like behavioral alterations were commonly induced in the NC, IM, and NC-IM groups and the therapeutic involvement of CB receptors was shown, there were discrepancies in the types of effective CB ligands between the working memory- and Anxiety-related behaviors.

Molecular neuroscience at its “high”: bibliometric analysis of the most cited papers on endocannabinoid system, cannabis and cannabinoids

The top-ranked manuscripts among the 100 were concerning analgesia, weight loss, long-term potentiation, depolarization-induced suppression of inhibition, opiates and other topics, and comprise the most highly cited publications in the topic.



Molecular characterization of a peripheral receptor for cannabinoids

The cloning of a receptor for cannabinoids is reported that is not expressed in the brain but rather in macrophages in the marginal zone of spleen, which helps clarify the non-psychoactive effects of cannabinoids.

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

The cloning and expression of a complementary DNA that encodes a G protein-coupled receptor that is involved in cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana are suggested.

Modulation of anxiety through blockade of anandamide hydrolysis

The results indicate that anandamide participates in the modulation of emotional states and point to fatty acid amide hydrolase inhibition as an innovative approach to anti-anxiety therapy.

Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal.

It is suggested that long-term cannabinoid administration alters CRF function in the limbic system of the brain, in a manner similar to that observed with other drugs of abuse, and also induces neuroadaptive processes that may result in future vulnerability to drug dependence.

Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-Administration

The present results show the existence of a cross-interaction between opioid and cannabinoid systems in behavioral responses related to addiction and open new strategies for the treatment of opiate dependence.

A cannabinoid mechanism in relapse to cocaine seeking

It is reported here that the synthetic cannabinoid agonist, HU210, provokes relapse to cocaine seeking after prolonged withdrawal periods, and the selective CB1 receptor antagonist, SR141716A, attenuates relapse induced by re-exposure to cocaine-associated cues or cocaine itself, but not relapseinduced by exposure to stress.

Determination and characterization of a cannabinoid receptor in rat brain.

The criteria for a high affinity, stereoselective, pharmacologically distinct cannabinoid receptor in brain tissue have been fulfilled.

Cannabinoid receptor localization in brain.

  • M. HerkenhamA. Lynn K. Rice
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1990
The potencies of a series of natural and synthetic cannabinoids as competitors of [3H]CP 55,940 binding correlated closely with their relative potencies in several biological assays, suggesting that the receptor characterized in the in vitro assay is the same receptor that mediates behavioral and pharmacological effects of cannabinoids, including human subjective experience.

Isolation and structure of a brain constituent that binds to the cannabinoid receptor.

Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in a screen for endogenous ligands for the cannabinoid receptor. The structure of this compound, which has

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

It is reported that anandamide is produced in and released from cultured brain neurons in a calcium ion-dependent manner when the neurons are stimulated with membrane-depolarizing agents, indicating that multiple biochemical pathways may participate in an andamide formation in brain tissue.