The endogenous cannabinoid system and drug addiction: 20 years after the discovery of the CB1 receptor

@article{RodrguezdeFonseca2008TheEC,
  title={The endogenous cannabinoid system and drug addiction: 20 years after the discovery of the CB1 receptor},
  author={Fernando Rodr{\'i}guez de Fonseca and Miriam Schneider},
  journal={Addiction Biology},
  year={2008},
  volume={13}
}
Cannabis sativa preparations (hashish, marijuana) have been used by humans for the last 5000 years. But being one of the oldest recreational drugs with abuse potential, its neurobiological mechanisms remained obscure until the isolation and identification in 1964 of Dtetrahydrocannabinol (THC), its main psychoactive constituent, by the group of Ralph Mechoulam (Gaoni & Mechoulam 1964). THC was the first of a series of a new class of drugs termed cannabinoids, but despite this finding, the brain… 

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