The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.

@article{Cota2003TheEC,
  title={The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.},
  author={Daniela Cota and Giovanni Marsicano and Matthias H. Tsch{\"o}p and Yvonne Gr{\"u}bler and Cornelia Flachskamm and Mirjam I Schubert and D. R. Auer and Alexander Yassouridis and Christa Th{\"o}ne-Reineke and Sylvia Ortmann and Federica Tomassoni and Cristina Cervino and Enzo Nisoli and Astrid C. E. Linthorst and Renato Pasquali and Beat Lutz and G{\"u}nter K. Stalla and Uberto Pagotto},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={112 3},
  pages={
          423-31
        }
}
The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in the regulation of food intake. Here we show that the lack of CB1 in mice with a disrupted CB1 gene causes hypophagia and leanness. As compared with WT (CB1+/+) littermates, mice lacking CB1 (CB1-/-) exhibited reduced spontaneous caloric intake and, as a consequence of reduced total fat mass, decreased body weight. In young CB1-/- mice, the lean phenotype is predominantly caused by decreased… 

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