The endogenous cannabinoid receptor agonist anandamide impairs memory in rats

  title={The endogenous cannabinoid receptor agonist anandamide impairs memory in rats},
  author={Paul E. Mallet and Richard J. Beninger},
  journal={Behavioural Pharmacology},
Anandamide was recently discovered to be an endogenous substance that acts as a partial agonist at cannabinoid receptors in the central nervous system. Because exogenous cannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC), the principal psychoactive ingredient of marijuana, have been found to impair memory, we undertook the present study to examine the mnemonic effects of anandamide. Memory was assessed in rats well-trained in a two-component instrumental discrimination task with a… 
The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by Δ9-tetrahydrocannabinol or anandamide
This is the first report that the memory impairment produced by anandamide can be attenuated by a cannabinoid antagonist; results suggest that an andamide-induced memory disruption is mediated by CB1 receptors.
Delta9-tetrahydrocannabinol, but not the endogenous cannabinoid receptor ligand anandamide, produces conditioned place avoidance.
The results fail to implicate the endogenous cannabinoid anandamide in reward-related learning or aversion and the half-life of an andamide was increased by pretreatment with the protease inhibitor phenylmethylsulfonyl fluoride.
Beninger The cannabinoid CB 1 receptor antagonist SR 141716 A attenuates the memory impairment produced by ∆ 9-tetrahydrocannabinol or anandamide
  • 1998
The administration of ∆9-tetrahydrocannabinol (THC), the principle psychoactive ingredient in marijuana, or the endogenous cannabinoid anandamide, has been shown to impair recent memory. The purpose
A second endogenous cannabinoid that modulates long-term potentiation
2-AG activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3–CA1 synapses, indicating that 2-AG is a second endogenous cannabinoid ligand in the central nervous system.
Cannabinoids alter recognition memory in rats.
First evidence that cannabinoids impair recognition memory in rats is found, as a stable analogue of endogenous cannabinoid anandamide and a potent CB(1) receptor agonist, CP 55,940 significantly attenuated recognition memory.
Improvement of memory in rodents by the selective CB1 cannabinoid receptor antagonist, SR 141716
The results strongly support the concept that blockade of CB1 receptors plays an important role in consolidation of short-term memory in rodents and suggest there may be a role for an endogenous cannabinoid agonist tone (anandaminergic) in forgetting.
Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats
Five structurally different FAAH inhibitors are determined in an animal model of working memory known to be sensitive to impairment by delta-9 tetrahydrocannabinol (THC) and their potential for memory impairment, abuse liability, and probably other cannabis-like effects are determined.
Differential effects of Δ9-THC on spatial reference and working memory in mice
Abstract. Rationale: Marijuana remains the most widely used illicit drug in the U.S., and recent attention has been given to putative therapeutic uses of marijuana and cannabinoid derivatives. Thus,
SR 141716A enhances spatial memory as assessed in a radial-arm maze task in rats.
  • A. Lichtman
  • Psychology, Medicine
    European journal of pharmacology
  • 2000
Evidence is provided supporting the hypothesis that endogenous cannabinoid systems play a role in memory processes byificantly fewer errors were committed during the test phase following an injection of SR 141716A than the vehicle treatment.
Effects of SR 141716A after acute or chronic cannabinoid administration in dogs.
Interestingly, SR 141716A was able to precipitate a withdrawal syndrome in delta9-tetrahydrocannabinol-tolerant dogs, but failed to produce any observable effects in dogs receiving chronic vehicle injections.