The endogenous cannabinoid receptor agonist anandamide impairs memory in rats

  title={The endogenous cannabinoid receptor agonist anandamide impairs memory in rats},
  author={P. Mallet and R. J. Beninger},
  journal={Behavioural Pharmacology},
  • P. Mallet, R. J. Beninger
  • Published 1996
  • Psychology
  • Behavioural Pharmacology
  • Anandamide was recently discovered to be an endogenous substance that acts as a partial agonist at cannabinoid receptors in the central nervous system. Because exogenous cannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC), the principal psychoactive ingredient of marijuana, have been found to impair memory, we undertook the present study to examine the mnemonic effects of anandamide. Memory was assessed in rats well-trained in a two-component instrumental discrimination task with a… CONTINUE READING
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