The endogenous cannabinoid receptor agonist anandamide impairs memory in rats

@article{Mallet1996TheEC,
  title={The endogenous cannabinoid receptor agonist anandamide impairs memory in rats},
  author={Paul E. Mallet and Richard J. Beninger},
  journal={Behavioural Pharmacology},
  year={1996},
  volume={7},
  pages={276–284}
}
Anandamide was recently discovered to be an endogenous substance that acts as a partial agonist at cannabinoid receptors in the central nervous system. Because exogenous cannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC), the principal psychoactive ingredient of marijuana, have been found to impair memory, we undertook the present study to examine the mnemonic effects of anandamide. Memory was assessed in rats well-trained in a two-component instrumental discrimination task with a… Expand
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