The endogenous cannabinoid anandamide inhibits cromakalim-activated K+ currents in follicle-enclosed Xenopus oocytes.

@article{Oz2007TheEC,
  title={The endogenous cannabinoid anandamide inhibits cromakalim-activated K+ currents in follicle-enclosed Xenopus oocytes.},
  author={Murat Oz and Keun-Hang Yang and Meral Dinç and Toni Shaun Shippenberg},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={323 2},
  pages={
          547-54
        }
}
The effect of the endogenous cannabinoid anandamide on K(+) currents activated by the ATP-sensitive potassium (K(ATP)) channel opener cromakalim was investigated in follicle-enclosed Xenopus oocytes using the two-electrode voltage-clamp technique. Anandamide (1-90 microM) reversibly inhibited cromakalim-induced K(+) currents, with an IC(50) value of 8.1 +/- 2 microM. Inhibition was noncompetitive and independent of membrane potential. Coapplication of anandamide with the cannabinoid type 1 (CB… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

Opening of glibenclamide-sensitive K+ channels in follicular cells promotes Xenopus oocyte maturation.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1992
VIEW 14 EXCERPTS
HIGHLY INFLUENTIAL

Hormone-regulated K+ channels in follicle-enclosed oocytes are activated by vasorelaxing K+ channel openers and blocked by antidiabetic sulfonylureas.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1991
VIEW 17 EXCERPTS
HIGHLY INFLUENTIAL

Effect of anandamide on cytosolic Ca(2+) levels and proliferation in canine renal tubular cells.

  • Basic & clinical pharmacology & toxicology
  • 2006
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Cocaine inhibits cromakalim-activated K+ currents in follicle-enclosed Xenopus oocytes

Murat Oz, Irina Zakharova, Meral Dinc, Toni Shippenberg
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2003
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL