The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite.
@article{Shang2016TheEC, title={The endogenous cannabinoid anandamide increases human airway epithelial cell permeability through an arachidonic acid metabolite.}, author={Valerie C. M. Shang and Saoirse Elizabeth O'Sullivan and David A. Kendall and R E Roberts}, journal={Pharmacological research}, year={2016}, volume={105}, pages={ 152-63 } }
16 Citations
Expression of endocannabinoid system components in human airway epithelial cells: impact of sex and chronic respiratory disease status
- Biology, MedicineERJ Open Research
- 2020
The data suggest that cannabis consumers may have differential physiological responses in the respiratory mucosa, and confirm at the protein level that TRPV1, the most differentially expressed candidate in analyses, was upregulated in airway epithelial cells from people with asthma relative to healthy subjects.
Endocannabinoid System in the Airways
- BiologyMolecules
- 2019
The contribution of cannabinoids and the endocannabinoid system in the airways are discussed, and the existing data for their therapeutic use in airway diseases are presented.
Impact of Cannabis, Cannabinoids, and Endocannabinoids in the Lungs
- BiologyFront. Pharmacol.
- 2016
The existing data on the regulation of lung immunity and inflammation by phytocannabinoid, synthetic cannabinoids and endocannabinoids is presented.
Expression of the endocannabinoid system in the human airway epithelial cells – Impact of sex and chronic respiratory disease status
- Biology, MedicinebioRxiv
- 2020
The data suggest that cannabis consumers may have differential physiological responses in the respiratory mucosa, which could impact both acute and chronic effects of cannabis smoke inhalation.
Polarity scaffolds signaling in epithelial cell permeability.
- BiologyInflammation research : official journal of the European Histamine Research Society ... [et al.]
- 2021
The potential effects of endo- and phytocannabinoids on epithelial permeability and how the dysregulation of this system could be involved in diseases and targeted for therapy are discussed.
Untapped Potential: Therapeutically Targeting Eicosanoids and Endocannabinoids in the Lung
- BiologyClinical pharmacology and therapeutics
- 2021
This review seeks to provide a summary of the major bioactive eicosanoids and endocannabinoids, challenges facing researchers that study them, and their roles in modulating inflammation and resolution.
Human laryngeal squamous cell carcinoma cell line release of endogenous anandamide and 2-arachidonoylglycerol, and their antiproliferative effect via exogenous supplementation: an in vitro study
- BiologyCell and tissue banking
- 2021
It is shown that the HEp-2 LSCC cell line releases the major endocannabinoids AEA and 2-AG, and that their supplementation inhibits tumor cell proliferation in vitro, suggesting that cannabinoid ligands might represent novel drug candidates for laryngeal cancers, although functional in vivo studies are required in order to validate their potency.
The Role of the Endocannabinoid Signaling System in the Pathophysiology of Asthma and Obesity
- Medicine, BiologyAnnals of the Russian academy of medical sciences
- 2019
The wide prevalence of the endocannabinoid signaling system and its regulatory role in the body opens up prospects for therapeutic effects in the treatment of asthma and obesity, as well as the possible phenotype of asthma, combined with obesity.
Elucidating the metabolism of n-3 polyunsaturated fatty acids and formation of bioactive lipid mediators in human skin
- Biology, Medicine
- 2017
The findings suggest that EPA and DHA differently affect skin cells and skin, with EPA preference in epidermis and D HA in the dermis, and the importance of differential skin responses that could be important in skin health and disease is highlighted.
The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations
- Biology, MedicineInternational journal of molecular sciences
- 2017
The anti-asthma mechanism of Modified Kushen Gancao Formula can be achieved through the comprehensive regulation of multiple perturbed biomarkers and metabolic pathways.
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