The endogenous cannabinoid 2‐arachidonoyl glycerol as in vivo chemoattractant for dendritic cells and adjuvant for Th1 response to a soluble protein

  title={The endogenous cannabinoid 2‐arachidonoyl glycerol as in vivo chemoattractant for dendritic cells and adjuvant for Th1 response to a soluble protein},
  author={Georges J. M. Maestroni},
  journal={The FASEB Journal},
  • G. Maestroni
  • Published 1 December 2004
  • Biology
  • The FASEB Journal
The decision‐making mechanisms that determine the choice of the appropriate effector immune response to a microbial challenge are poorly understood. The endocannabinoid 2‐ arachidonoylglycerol (2‐AG), injected intradermally in mice together with a soluble protein and a T helper‐2 (Th2) priming Toll‐like receptors (TLRs) agonist during primary immunization, shifts the memory response to the Th1 type. This effect can be shown by the enhanced hypersensitivity response and by the Th1 pattern of… 

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and De Novo Leukotriene B Neutrophils: Critical Role of Its Hydrolysis 2-Arachidonoyl-Glycerol Activates Human The Endocannabinoid

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Cutting Edge: Different Toll-Like Receptor Agonists Instruct Dendritic Cells to Induce Distinct Th Responses via Differential Modulation of Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Kinase and c-Fos 1

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Differential Induction of Interleukin-10 and Interleukin-12 in Dendritic Cells by Microbial Toll-Like Receptor Activators and Skewing of T-Cell Cytokine Profiles

The results support the notion that microbe-specific information sensed through different TLRs by DCs is linked to differential Th priming through DC-derived cytokines.

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The results strongly suggest that the CB2 receptor and its physiological ligand, i.e., 2-arachidonoylglycerol, play important regulatory roles such as stimulation of the production of chemokines in inflammatory cells and immune-competent cells.

Langerhans cells β2-adrenoceptors: role in migration, cytokine production, Th priming and contact hypersensitivity

Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol.

It is demonstrated that in retrovirally induced murine myeloid leukemia cells with proviral insertion in Cb2, exon-1B/exon-2 C b2 messenger RNA levels have been increased, resulting in high receptor numbers, and a major function of the Cb1 receptor is stimulation of migration as determined in a transwell assay.