The endogenous adjuvant squalene can induce a chronic T-cell-mediated arthritis in rats.

@article{Carlson2000TheEA,
  title={The endogenous adjuvant squalene can induce a chronic T-cell-mediated arthritis in rats.},
  author={Brett Carlson and Anna M. Jansson and Anders Larsson and Anders Bucht and J C Lorentzen},
  journal={The American journal of pathology},
  year={2000},
  volume={156 6},
  pages={2057-65}
}
Squalene is a cholesterol precursor, which stimulates the immune system nonspecifically. We demonstrate that one intradermal injection of this adjuvant lipid can induce joint-specific inflammation in arthritis-prone DA rats. Histopathological and immunohistochemical analyses revealed erosion of bone and cartilage, and that development of polyarthritis coincided with infiltration of alphabeta(+) T cells. Depletion of these cells with anti-alphabeta TcR monoclonal antibody (R73) resulted in… CONTINUE READING