The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis.

@article{Wiley1982TheER,
  title={The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis.},
  author={H. Steven Wiley and Dennis D. Cunningham},
  journal={The Journal of biological chemistry},
  year={1982},
  volume={257 8},
  pages={4222-9}
}
The endocytotic rate constant (k,) is a cellular constant which defines the probability of an occupied receptor being internalized in 1 min at 37 "C. We have derived an equation that expresses the relationship between k, and the relative amount of surface-bound and internalized ligand as a function of time. This equation was used as the basis for a graphical form of analysis called the In/Sur plot. This plot directly yields k, as well as the lag time that exists between ligand internalization… CONTINUE READING
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