The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain.

@article{Tong2000TheEP,
  title={The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain.},
  author={Xin-Kang Tong and Natasha K. Hussain and Elaine de Heuvel and Alexei Kurakin and Elia Abi-Jaoude and Christopher C. Quinn and Michael F Olson and Richard Marais and Danny Baranes and Brian K. Kay and Peter S McPherson},
  journal={The EMBO journal},
  year={2000},
  volume={19 6},
  pages={1263-71}
}
We recently identified intersectin, a protein containing two EH and five SH3 domains, as a component of the endocytic machinery. The N-terminal SH3 domain (SH3A), unlike other SH3 domains from intersectin or various endocytic proteins, specifically inhibits intermediate events leading to the formation of clathrin-coated pits. We have now identified a brain-enriched, 170 kDa protein (p170) that interacts specifically with SH3A. Screening of combinatorial peptides reveals the optimal ligand for… CONTINUE READING
30 Citations
64 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 64 references

Similar Papers

Loading similar papers…