The endocytic pathway in microglia during health, aging and Alzheimer’s disease

@article{SolDomnech2016TheEP,
  title={The endocytic pathway in microglia during health, aging and Alzheimer’s disease},
  author={Santiago Sol{\'e}-Dom{\`e}nech and Dana L Cruz and Estibaliz Capetillo-Zarate and Frederick R Maxfield},
  journal={Ageing Research Reviews},
  year={2016},
  volume={32},
  pages={89-103}
}
Microglia, the main phagocytes of the central nervous system (CNS), are involved in the surveillance and maintenance of nervous tissue. During normal tissue homeostasis, microglia migrates within the CNS, phagocytose dead cells and tissue debris, and modulate synapse pruning and spine formation via controlled phagocytosis. In the event of an invasion by a foreign body, microglia are able to phagocytose the invading pathogen and process it proteolytically for antigen presentation. Internalized… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 206 references

Trafficking and proteolytic processing of APP.

Cold Spring Harbor perspectives in medicine • 2012
View 12 Excerpts
Highly Influenced

Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 7 Excerpts
Highly Influenced

The cell biology of phagocytosis.

Annual review of pathology • 2012
View 16 Excerpts
Highly Influenced

CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010
View 5 Excerpts
Highly Influenced

Trophic macrophages in development and disease

Nature Reviews Immunology • 2009
View 4 Excerpts
Highly Influenced

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