The endocytic pathway and formation of the Wingless morphogen gradient.

@article{Marois2005TheEP,
  title={The endocytic pathway and formation of the Wingless morphogen gradient.},
  author={Eric Marois and Ali Ahmad El-Haj Mahmoud and Suzanne Eaton},
  journal={Development},
  year={2005},
  volume={133 2},
  pages={
          307-17
        }
}
Controlling the spread of morphogens is crucial for pattern formation during development. In the Drosophila wing disc, Wingless secreted at the dorsal-ventral compartment boundary forms a concentration gradient in receiving tissue, where it activates short- and long-range target genes. The glypican Dally-like promotes Wingless spreading by unknown mechanisms, while Dynamin-dependent endocytosis is thought to restrict Wingless spread. We have utilized short-term expression of dominant negative… CONTINUE READING

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