The endocytic machinery in nerve terminals surrounds sites of exocytosis

@article{Roos1999TheEM,
  title={The endocytic machinery in nerve terminals surrounds sites of exocytosis},
  author={Jack Roos and Regis B. Kelly},
  journal={Current Biology},
  year={1999},
  volume={9},
  pages={1411-1414}
}
In most models of endocytosis, the endocytic machinery is recruited from the cytoplasm by cytoplasmic tails of the plasma membrane proteins that are to be internalized. This does not appear to be true at synapses where the endocytic machinery required for synaptic vesicle recycling is localized to membrane-associated 'hot spots' [1] [2]. In Drosophila neuromuscular junctions, the multi-domain protein Dap160 is also localized to hot spots [3] and has some characteristics expected of an anchoring… CONTINUE READING
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