The endocrinology of perimenopause: need for a paradigm shift.

@article{Prior2011TheEO,
  title={The endocrinology of perimenopause: need for a paradigm shift.},
  author={Jerilynn C Prior and Christine Laura Hitchcock},
  journal={Frontiers in bioscience},
  year={2011},
  volume={3},
  pages={474-86}
}
Perimenopause, rather than a time of declining estrogen, is characterized by three major hormonal changes that may begin in regularly menstruating women in their mid-thirties: erratically higher estradiol levels, decreased progesterone levels (in normally ovulatory, short luteal phase or anovulatory cycles), and disturbed ovarian-pituitary-hypothalamic feedback relationships. Recent data show that approximately a third of all perimenopausal cycles have a major surge in estradiol occurring de… CONTINUE READING