The endocrine effects of ketoconazole

@article{Sonino1986TheEE,
  title={The endocrine effects of ketoconazole},
  author={N. Sonino},
  journal={Journal of Endocrinological Investigation},
  year={1986},
  volume={9},
  pages={341-347}
}
  • N. Sonino
  • Published 1986
  • Medicine
  • Journal of Endocrinological Investigation
  • INTRODUCTION Ketoconazole l has been employed extensively in clinical practice during the last 5 years as an innovative treatment for fungal disease (1 ). This is due largely to its properties: broad-spectrum activity, easy mode of administration, widespread tissue distribution, low degree of inactivation, good patient tolerance, low toxicity profile (2). This orally-active imidazole derivative (3-5) interferes with the synthesis of ergosterol in fungi and cholesterol in mammalian cells by… CONTINUE READING
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