The endocrine disrupting chemical, diethylhexyl phthalate, activates MDR1 gene expression in human colon cancer LS174T cells.

@article{Takeshita2006TheED,
  title={The endocrine disrupting chemical, diethylhexyl phthalate, activates MDR1 gene expression in human colon cancer LS174T cells.},
  author={Akira Takeshita and Keiji Inagaki and Junko Igarashi-Migitaka and Yasunori Ozawa and Noriyuki Koibuchi},
  journal={The Journal of endocrinology},
  year={2006},
  volume={190 3},
  pages={897-902}
}
Resistance to anticancer drugs is often mediated by the overexpression of P-glycoprotein encoded by the multi-drug resistance (MDR1) gene. The nuclear receptor, steroid and xenobiotic receptor (SXR), is one of the key transcriptional regulators of MDR1 gene expression. A variety of xenobiotics bind to SXR, and stimulate transcription on xenobiotic-response elements (XREs), located in the MDR1 gene promoter. Diethylhexyl phthalate (DEHP) is widely used as a plasticizer for polyvinyl chloride… CONTINUE READING