The endocannabinoid system is modulated in response to spinal cord injury in rats

@article{GarciaOvejero2009TheES,
  title={The endocannabinoid system is modulated in response to spinal cord injury in rats},
  author={Daniel Garcia-Ovejero and Ángel Arévalo-Martı́n and Stefania Petrosino and Fabian Docagne and Carlos Hagen and Tiziana Bisogno and Masahiko Watanabe and Carmen Guaza and Vincenzo Di Marzo and Eduardo Molina-Holgado},
  journal={Neurobiology of Disease},
  year={2009},
  volume={33},
  pages={57-71}
}

Figures and Tables from this paper

Role of Endocannabinoids in Neuron-Glial Crosstalk
TLDR
Although eCBs are emerging as neurotransmitters responsible for the regu- lation of glia-neuron crosstalk in chronic pain, the precise mechanisms leading to eCB production, the origin and the time- course of e CB release, the eCB release switch from one cell type to the other and their movement or catabolism across the glial or neural cell membrane nevertheless still remain unknown.
The Endocannabinoid System and Oligodendrocytes in Health and Disease
TLDR
In several models of rodent encephalomyelitis, chronic treatment with cannabinoid agonists ameliorated the damage by promoting OPC survival and oligodendrocyte function by promoting cannabinoid receptor-mediated ERK pathways.
Palmitoylethanolamide in homeostatic and traumatic central nervous system injuries.
TLDR
An overview of current knowledge of PEA effect on glial functions in the brain and how targeting glial-specific pathways might ultimately impact the development of therapies for clinical management of neurodegenerative disorders is provided.
The role of endocannabinoids in pain modulation
TLDR
The purpose of this review is to present the available research and clinical data, up to date, regarding the ES and its role in pain modulation, as well as its possible therapeutic perspectives.
The neuroprotective role of endocannabinoids against chemical‐induced injury and other adverse effects
TLDR
The purpose of this review is to present the available in vivo and in vitro experimental data, up to date, regarding the endocannabinoid system and its role in neuroprotection, as well as its possible therapeutic perspectives.
Involvement of the endocannabinoid system in periodontal healing.
...
...

References

SHOWING 1-10 OF 146 REFERENCES
Protective activation of the endocannabinoid system during ischemia in dopamine neurons
Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats
Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17β‐estradiol
TLDR
It is shown that the endocannabinoid system is implicated in the pathophysiology of transient middle cerebral artery occlusion‐induced brain damage, and that neuroprotection afforded by estrogen is coincident with a re‐establishment of anandamide levels in the ischemic striatum through a mechanism that needs to be investigated further.
Effects of Palmitoylethanolamide on Signaling Pathways Implicated in the Development of Spinal Cord Injury
TLDR
It is indicated that PEA reduces inflammation and tissue injury associated with SCI and suggest a regulatory role for endogenous PPAR-α signaling in the inflammatory response associated with spinal cord trauma.
Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection.
TLDR
It is shown that cell damage induced by EAE does not lead to increase in eCBs, even though cannabinoid receptors are functional because synthetic cannabinoid agonists are known to confine EAE-induced lesions, and IFN-gamma, which is released by primed T cells invading the CNS, disrupts eCB-mediated neuroprotection while maintaining functional cannabinoid receptors.
Anandamide, but not 2‐arachidonoylglycerol, accumulates during in vivo neurodegeneration
TLDR
Analysis of cannabinoid CB1 receptor mRNA expression and binding capacity revealed that cortical subfields exhibited an up‐regulation of these parameters following mild concussive head trauma and exposure to NMDA receptor blockade, which may suggest that mild to moderate brain injury may trigger elevated endocannabinoid activity via concomitant increase of anandamide levels, but not 2‐AG, andCB1 receptor density.
Downregulation of the CB1 Cannabinoid Receptor and Related Molecular Elements of the Endocannabinoid System in Epileptic Human Hippocampus
TLDR
Findings show that a neuroprotective machinery involving endocannabinoids is impaired in epileptic human hippocampus and imply that downregulation of CB1 receptors and related molecular components of the endoc cannabinoidoid system may facilitate the deleterious effects of increased network excitability.
...
...