The endocannabinoid system is modulated in response to spinal cord injury in rats

@article{GarciaOvejero2009TheES,
  title={The endocannabinoid system is modulated in response to spinal cord injury in rats},
  author={D. Garcia-Ovejero and {\'A}. Ar{\'e}valo-Martı́n and S. Petrosino and F. Docagne and E. Molina-Holgado},
  journal={Neurobiology of Disease},
  year={2009},
  volume={33},
  pages={57-71}
}
Endocannabinoids are lipid mediators with protective effects in many diseases of the nervous system. We have studied the modulation of the endocannabinoid system after a spinal cord contusion in rats. In early stages, lesion induced increases of anandamide and palmitoylethanolamide (PEA) levels, an upregulation of the synthesizing enzyme NAPE-phospholipase D and a downregulation of the degradative enzyme FAAH. In delayed stages, lesion induced increases in 2-arachidonoylglycerol and a strong… Expand
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