The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis.

@article{Centonze2007TheES,
  title={The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis.},
  author={Diego Centonze and Monica Bari and Silvia Rossi and Chiara Prosperetti and Roberto Furlan and Filomena Fezza and Valentina De Chiara and Luca Battistini and Giorgio Bernardi and Sergio Bernardini and Gianvito Martino and Mauro Maccarrone},
  journal={Brain : a journal of neurology},
  year={2007},
  volume={130 Pt 10},
  pages={
          2543-53
        }
}
The ability of cannabinoids to modulate both inflammatory and degenerative neuronal damage prompted investigations on the potential benefits of such compounds in multiple sclerosis (MS) and in animal models of this disorder. Here we measured endocannabinoid levels, metabolism and binding, and physiological activities in 26 patients with MS (17 females, aged 19-43 years), 25 healthy controls and in mice with experimental autoimmune encephalomyelitis (EAE), a preclinical model of MS. Our results… 

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